Faculty
Ralph Corey, MD - HYC Director | Christopher Woods, MD - HYC Co-Director | John Hamilton, MD
John Bartlett, MD | Nathan
Thielman, MD | Vance Fowler, MD |
David Walmer, MD
Carol Dukes Hamilton,
MD | J. Brice Weinberg MD | Barth Reller MD | John Crump MD
Kathleen Clem, MD |
Truls Ostbye, MD, PhD | Kathryn Whetten, PhD | Dennis Clements, MD, PhD
Cheryl Baker, MD
Staff
Cynthia Binanay, RN, BSN, MA - HYC Program Director | Cecelia Pezdek - Global Health Residency Program Coordinator | Carlee Reimer - HYC Program Assistant
J. Brice Weinberg, M.D.
Dr. Weinberg is Professor of Medicine and Professor of Immunology at the Duke University School of Medicine, and Associate Chief of Staff for Research and Development at the Durham VA Medical Center. He is board certified in Hematology and Medical Oncology. Dr. Weinberg's research revolves around studies involving various aspects of mononuclear phagocyte (monocyte and macrophage) biology, with a focus on nitric oxide. The work includes studies of resistance to infection, pathways of inflammation, and regulation of normal and leukemic hematopoiesis. He is currently funded by the NIH and the VA for his research studies.
Dr. Weinberg is the Principal Investigator on an NIH grant looking at the importance of nitric oxide (NO) and inducible NO synthase (NOS2) in resistance to malaria in humans. His work in global health and tropical medicine has taken him to Tanzania, Kenya, Gabon, and Papua and Indonesia. NOS2 promoter single nucleotide polymorphisms (SNP) and SNP haplotypes in Africans determine levels of NO production in vivo, and correlate closely with resistance to clinical malaria. Also, he has shown that Africans and Indonesians with severe malaria have markedly low levels of the NOS substrate arginine. His research has shown that resistance to malaria likely results from a combination of genetic polymorphisms in NOS2 as well as deficiencies of arginine. He is working to understand the biologic bases of hypoargininemia. He is approaching therapy for prevention and treatment of clinical malaria with arginine administration and treatments to increase NOS expression.